奥赛利定联合艾司氯胺酮预防性镇痛对腹腔镜全子宫切除术患者术后疼痛、情绪状态和认知功能的影响

Effects of oliceridine combined with esketamine for prophylactic analgesia on postoperative pain, emotional states and cognitive function in patients undergoing laparoscopic total hysterectomy

中文关键词: 奥赛利定  艾司氯胺酮  腹腔镜全子宫切除术  术后疼痛  情绪状态  认知功能

英文关键词: oliceridine  esketamine  laparoscopic total hysterectomy  postoperative pain  emotional states  cognitive function

中文摘要:

      【】目的:探讨奥赛利定(OLI)联合艾司氯胺酮(ES)对腹腔镜全子宫切除术(LTH)患者术后疼痛、情绪状态和认知功能的影响。方法:选择徐州医科大学附属邳州医院2024年1月~2024年12月60例LTH患者,随机分为ES组和OLI联合ES组(OES组)各30例。麻醉诱导前5min,ES组静注ES 0.25mg/kg,OES组在ES组基础上静注OLI 1mg。比较两组术后疼痛(术后6h、12h、24h、48h的VAS评分)、情绪状态(术前1d、术后3d、5d的SAS评分、SDS评分)和认知功能(术前1d、术后3d、5d的MMSE评分)。结果:OES组术后6h、12h、24h的VAS评分低于ES组(P<0.05)。OES组术后3d、5d的SAS评分、SDS评分低于低于ES组(P<0.05)。OES组术后3d、5d的MMSE评分高于ES组(P<0.05)。结论:OLI联合ES预防性镇痛减轻LTH患者的术后疼痛,改善情绪状态,提高认知功能。

英文摘要:

      Objective: To investigate the effects of oliceridine (OLI) combined with esketamine (ES) for prophylactic analgesia on postoperative pain, emotional states and cognitive function in patients undergoing laparoscopic total hysterectomy (LTH). Methods: 60 patients with LTH in Pizhou Hospital Affiliated to Xuzhou Medical University from January 2024 to December 2024, were randomly divided into group ES and OLI combined with ES group (group OES), with 30 cases in each group. Five minutes before anesthesia induction, patients in group ES were intravenously injected with ES 0.25mg/kg, and patients in group OES were intravenously injected with OLI 1mg on the basis of group ES. Postoperative pain (VAS scores at 6h, 12h, 24h and 48h after operation), emotional states (SAS scores and SDS scores at 1st before operation, 3rd and 5th after operation) and cognitive function (MMSE scores at 1st before operation, 3rd and 5th after operation) were compared in the two groups. Results: VAS scores at 6h, 12h and 24h after operation in group OES were lower than those in group ES (P<0.05). SAS scores and SDS scores in group OES were lower than those in group ES at 3rd and 5th after operation (P<0.05). MMSE scores in group OES were higher than those in group ES at 3rd and 5th after operation (P<0.05). Conclusion: OLI combined with ES for prophylactic analgesia can reduce postoperative pain, improve emotional state and cognitive function in patients with LTH.