法舒地尔联合尼莫地平治疗脑动脉瘤栓塞术后脑血管痉挛疗效观察

Therapeutic effect of fasudil combined with nimodipine on cerebral vasospasm after cerebral aneurysm embolization

中文关键词: 脑动脉瘤栓塞术  脑血管痉挛  尼莫地平  法舒地尔

英文关键词: Cerebral aneurysm embolization  Cerebral vasospasm  Nimodipine  Fasudil

中文摘要:

      目的：探讨脑动脉瘤栓塞术后脑血管痉挛临床治疗中联合应用法舒地尔、尼莫地平的效果。方法：以2018年4月至2019年4月本院接收的58例脑动脉瘤栓塞术后发生脑血管痉挛的患者为研究对象，以随机双盲法为参考进行分组，即观察组（29例）、对照组（29例）；对照组行尼莫地平治疗，观察组行尼莫地平＋法舒地尔治疗，比对两组患者治疗前后的意识状态（GCS）评分、日常生活质量（Barthel）指数、神经功能缺损（NFI）评分以及大脑中动脉平均血流速度（MCA）。结果：两组患者治疗前的观察指标基本一致，即对应数据组间差异统计学意义不成立（P＞0.05）；治疗后，观察组患者的GCS评分、Barthel指数高于对照组，NFI评分低于对照组，MCA高于对照组，即组间差异有明显的统计学意义存在（P＜0.05）。结论：脑动脉瘤栓塞术后脑血管痉挛临床治疗中联合应用法舒地尔、尼莫地平效果较为显著，可以改善患者的临床症状与神经功能，对患者康复有积极作用。

英文摘要:

      Objective: To investigate the effect of fasudil and nimodipine in the clinical treatment of cerebral vasospasm after cerebral aneurysm embolization. Methods: A total of 58 patients with cerebral vasospasm who underwent cerebral aneurysm embolization received from our hospital from April 2018 to April 2019 were enrolled in the study. The random double-blind method was used as a reference group. Example), control group (29 cases); control group treated with nimodipine, observation group treated with nimodipine ＋ fasudil, compared with the two groups of patients before and after treatment (GCS) score, quality of daily life ( Barthel index, neurological deficit (NFI) score, and mean middle cerebral artery flow velocity (MCA). Results: The pre-treatment observations of the two groups were basically the same, that is, the statistical significance of the difference between the corresponding data groups was not established (P＞0.05). After treatment, the GCS score and Barthel index of the observation group were higher than the control group, and the NFI score was lower than that of the control group. In the control group, MCA was higher than the control group, that is, there was a statistically significant difference between the groups (P＜0.05). Conclusion: The combination of fasudil and nimodipine in the clinical treatment of cerebral vasospasm after cerebral aneurysm embolization is effective, which can improve the clinical symptoms and neurological function of patients, and has a positive effect on the rehabilitation of patients.