脑出血微创钻孔引流与尿激酶对颅内血块溶解的效果对比

Comparison of the effect of minimally invasive drilling drainage and urokinase on intracranial blood clot lysis in patients with cerebral hemorrhage

中文关键词: 微创钻孔引流  尿激酶  脑出血  颅内血块

英文关键词: Minimally invasive drilling drainage  Urokinase  Cerebral hemorrhage  Intracranial blood clot

中文摘要:

      目的：对比脑出血微创钻孔引流与尿激酶对颅内血块溶解的效果。方法：2018年4月到2019年4月选择在本院诊治的脑出血患者84例，随机分为两组。研究组给予微创钻孔引流治疗，对照组给予尿激酶治疗，记录颅内血块溶解效果。结果：治疗后观察组的总有效率显著高于对照组 (P<0.05)。治疗后观察组的血肿清除率显著高于对照组 (P<0.05)。治疗后两组的血清GFAP含量都显著低于治疗前，观察组也显著低于对照组(P<0.05)。观察组闭管时间及引流时间都显著少于对照组(P<0.05)。结论：相对于尿激酶，微创钻孔引流在脑出血中的应用能促进颅内血块溶解，抑制血清GFAP的释放，减少闭管时间及引流时间，从而提高治疗效果。

英文摘要:

      Objective: To compare the effects of minimally invasive drilling drainage and urokinase on intracranial blood clot lysis in patients with cerebral hemorrhage. Methods: From April 2018 to April 2019, 84 patients with cerebral hemorrhage were selected and divided into two groups. The study group was treated with minimally invasive drilling drainage, while the control group was treated with urokinase. The effect of intracranial blood clot dissolution was recorded. Results: After treatment, the total effective rate of the study group was significantly higher than that of the control group (P < 0.05). After treatment, the hematoma clearance rate in the study group was significantly higher than that in the control group (P < 0.05). After treatment, the serum GFAP content in both groups was significantly lower than that before treatment, and the study group was also significantly lower than that in the control group (P < 0.05). The closure time and drainage time of the study group were significantly less than those of the control group (P < 0.05). Conclusion: Compared with urokinase, the application of minimally invasive drilling drainage in cerebral hemorrhage can promote the dissolution of intracranial blood clots, inhibit the release of serum GFAP, reduce the time of closure and drainage, and thus improve the therapeutic effect.