西藏地区血氧饱和度、血常规、凝血功能等指标与妊娠并发症及结局的相关性分析

Analysis of blood oxygen saturation, blood routine and coagulation function with pregnancy complications in plateau areas

中文关键词: 高原地区  孕产妇  血氧饱和度  血常规  凝血指标  妊娠并发症

英文关键词: Plateau  Maternity blood oxygen  Saturation  Blood routine  Coagulation function  Pregnancy complications

中文摘要:

      目的：探讨西藏地区血氧饱和度、红细胞计数、血红蛋白含量、凝血功能等与妊娠并发症及不良结局发生的相关性，为高原产前保健提供参考依据。方法：采用回顾性研究方法，选取2019年1月至2020年1月本院出现妊娠并发症及不良结局的孕产妇146例（观察组）及正常孕产妇135例（对照组）。收集两组孕产妇一般情况、血氧饱和度、血常规、凝血状态指标、分娩方式、母婴相关并发症及不良结局等资料，比较两组间差异。结果：观察组红细胞计数、血红蛋白含量低于对照组，血浆D-二聚体高于对照组，两组间差异有统计学意义，P＜0.05。亚组分析不同并发症及结局，发生贫血的孕产妇红细胞计数、血红蛋白低于对照组，血浆D-二聚体高于对照组。发生妊娠期高血压疾病的孕产妇血红蛋白低于对照组，血浆D-二聚体高于对照组。低体质量儿的孕产妇红细胞计数、血红蛋白低于对照组，血浆D-二聚体高于对照组。早产的孕产妇红细胞计数低于对照组，血浆D-二聚体高于对照组。发生胎儿窘迫孕产妇红细胞计数、血红蛋白低于对照组，血浆D-二聚体高于对照组。差异有统计学意义，P＜0.05。结论：西藏地区孕产妇产前保健仍需加强。红细胞计数、血红蛋白、D-二聚体与西藏地区妊娠并发症及不良结局的发生可能有一定关系。对于红细胞计数、血红蛋白降低程度及血浆D-二聚体增高程度的判定及妊娠并发症的预测仍需后续研究。

英文摘要:

      Objective: To explore the correlation between blood oxygen saturation, red blood cell count, hemoglobin content, coagulation function and pregnancy complications, and provide reference for prenatal care in plateau areas. Methods: Retrospective study method was used to 146 pregnant women with pregnancy complications and 135 cases without pregnancy complications from January 2019 to January 2020. The data of general conditions, blood oxygen saturation, red blood cell count, hemoglobin content, coagulation function, pregnancy complications were collected, and the differences between the two groups were compared. Results: The red blood cell count and hemoglobin content in the observation group were lower than those of the control group, and the D-dimer was higher than that of the control group, P＜0.05. Patients with anemia had lower red blood cell count and hemoglobin than the control group, and D-dimer was higher than the control group， P＜0.05. Patients with pregnancy hypertension had lower hemoglobin than the control group, and D-dimer was higher than the control group，P＜0.05. Patients with low weight fetuses had lower red blood cell count, hemoglobin than the control group, and D-dimer was higher than the control group, P＜0.05. The red blood cell count in patients with premature birth was lower than that in the control group, and D-dimer was higher than that in the control group, P＜0.05. Patients with fetal distress had lower red blood cell count, hemoglobin than the control group, and higher D-dimer than the control group, P＜0.05. Conclusion: Maternal antenatal care still needs to be strengthened in plateau areas. Red blood cell count, hemoglobin, and D-dimer may have a certain relationship with complications of pregnancy in plateau areas. The determination of erythrocyte count, hemoglobin reduction and plasma D-dimer increase and the prediction of pregnancy complications still need to be studied.